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It was first synthesized by Alexander Shulgin. The drug is used recreationally for its psychedelic and entactogenic effects and is sometimes confused for the analog 25I-NBOMe, nicknamed "Smiles," in the media. Effects The onset of effects occurs between one to two hours when Seeking downtown texting friend orally, and 10—20 minutes when insufflated; lasting between 4 to 12 hours depending on the dose though some users have reported a duration of 16—18 hours. A shorter duration is typical for insufflated doses.
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